Control of vein-forming, striped gene expression by auxin signaling
| Autor: | Jason Gardiner, Anmol Krishna, Tyler J. Donner, Enrico Scarpella |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Arabidopsis thaliana Physiology QH301-705.5 Gene regulatory network Arabidopsis Gene Expression Plant Science 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Structural Biology Gene Expression Regulation Plant Gene expression Auxin Biology (General) Gene Transcription factor Psychological repression MONOPTEROS Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences biology Indoleacetic Acids Arabidopsis Proteins food and beverages Cell Biology biology.organism_classification Leaf vascular patterning Stripe formation Cell biology Homeobox General Agricultural and Biological Sciences Function (biology) 010606 plant biology & botany Developmental Biology Biotechnology Transcription Factors |
| Zdroj: | BMC Biology, Vol 19, Iss 1, Pp 1-19 (2021) |
| ISSN: | 1741-7007 |
| Popis: | Background Activation of gene expression in striped domains is a key building block of biological patterning, from the recursive formation of veins in plant leaves to that of ribs and vertebrae in our bodies. In animals, gene expression is activated in striped domains by the differential affinity of broadly expressed transcription factors for their target genes and the combinatorial interaction between such target genes. In plants, how gene expression is activated in striped domains is instead unknown. We address this question for the broadly expressed MONOPTEROS (MP) transcription factor and its target gene ARABIDOPSIS THALIANA HOMEOBOX FACTOR8 (ATHB8). Results We find that ATHB8 promotes vein formation and that such vein-forming function depends on both levels of ATHB8 expression and width of ATHB8 expression domains. We further find that ATHB8 expression is activated in striped domains by a combination of (1) activation of ATHB8 expression through binding of peak levels of MP to a low-affinity MP-binding site in the ATHB8 promoter and (2) repression of ATHB8 expression by MP target genes of the AUXIN/INDOLE-3-ACETIC-ACID-INDUCIBLE family. Conclusions Our findings suggest that a common regulatory logic controls activation of gene expression in striped domains in both plants and animals despite the independent evolution of their multicellularity. |
| Databáze: | OpenAIRE |
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