Bone repair following bone grafting hydroxyapatite guided bone regeneration and infra-red laser photobiomodulation: a histological study in a rodent model

Autor: Antonio Luiz Barbosa Pinheiro, Carolina Montagn Carvalho, Manuela Pimentel Noia, Francisco de Assis Limeira, Priscila Chagas Oliveira, Elizabeth Arruda Carneiro Ponzi, Luciana Maria Pedreira Ramalho, Marleny Elizabeth Martinez Gerbi, Rafael de Carneiro Santos, Aparecida Maria Cordeiro Marques
Rok vydání: 2008
Předmět:
Zdroj: Lasers in Medical Science. 24:234-240
ISSN: 1435-604X
0268-8921
DOI: 10.1007/s10103-008-0556-0
Popis: The aim of the investigation was to assess histologically the effect of laser photobiomodulation (LPBM) on a repair of defects surgically created in the femurs of rats. Forty-five Wistar rats were divided into four groups: group I (control); group II (LPBM); group III (hydroxyapatite guided bone regeneration; HA GBR); group IV (HA GBR LPBM). The animals in the irradiated groups were subjected to the first irradiation immediately after surgery, and it was repeated every day for 2 weeks. The animals were killed 15 days, 21 days and 30 days after surgery. When the groups irradiated with implant and membrane were compared, it was observed that the repair of the defects submitted to LPBM was also processed faster, starting from the 15th day. At the 30th day, the level of repair of the defects was similar in the irradiated groups and those not irradiated. New bone formation was seen inside the cavity, probably by the osteoconduction of the implant, and, in the irradiated groups, this new bone formation was incremental. The present preliminary data seem to suggest that LPMB therapy might have a positive effect upon early wound healing of bone defects treated with a combination of HA and GBR.
Databáze: OpenAIRE
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