Nanostructured Modulators of Neuroglia
| Autor: | Jeff Ji, Dusica Maysinger |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cell type
Central nervous system law.invention 03 medical and health sciences 0302 clinical medicine Confocal microscopy law Drug Discovery medicine Humans 030304 developmental biology Neurons Pharmacology 0303 health sciences Microglia Chemistry Nanostructures Cell biology medicine.anatomical_structure nervous system Colloidal gold Astrocytes Neuroglia Functional status 030217 neurology & neurosurgery |
| Zdroj: | Current Pharmaceutical Design. 25:3905-3916 |
| ISSN: | 1381-6128 |
| Popis: | Biological and synthetic nanostructures can influence both glia and neurons in the central nervous system. Neurons represent only a small proportion (about 10%) of cells in the brain, whereas glial cells are the most abundant cell type. Non-targeted nanomedicines are mainly internalized by glia, in particular microglia, and to a lesser extent by astrocytes. Internalized nanomedicines by glia indirectly modify the functional status of neurons. The mechanisms of biochemical, morphological and functional changes of neural cells exposed to nanomedicines are still not well-understood. This minireview provides a cross-section of morphological and biochemical changes in glial cells and neurons exposed to different classes of hard and soft nanostructures. |
| Databáze: | OpenAIRE |
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