Decreased Levels of Soluble CD44 in a High-Risk Population following a Smoking Cessation Program

Autor:	Drew H. Smith, Shahm Raslan, Isildinha M. Reis, Abdurrahman Al-Awady, Isabella Buitron, Melanie Perez, Huaping Liu, Jerri Halgowich, Claudia Gordon, Monica Webb Hooper, Noël C. Barengo, Elizabeth J. Franzmann
Rok vydání:	2021
Předmět:	Health Toxicology and Mutagenesis Smoking Public Health Environmental and Occupational Health total protein tobacco Article Hyaluronan Receptors solCD44 Head and Neck Neoplasms Risk Factors smoking intervention Humans Medicine Smoking Cessation head and neck cancer cotinine
Zdroj:	International Journal of Environmental Research and Public Health, Vol 18, Iss 13174, p 13174 (2021) International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health; Volume 18; Issue 24; Pages: 13174
ISSN:	1660-4601
DOI:	10.3390/ijerph182413174
Popis:	Tobacco is a risk factor of head and neck cancer (HNC) and smoking cessation alone may reduce HNC risk by 70%. Soluble CD44 (solCD44), a cell surface receptor linked to cell proliferation and migration, and total protein (TP) levels can detect early HNC. This study aims to determine whether salivary solCD44 and TP levels in oral rinses change following a smoking cessation program. 150 smokers provided oral rinse samples at baseline and at a 12-month follow-up after participation in a smoking cessation program. Assays to measure levels of solCD44, TP, and cotinine, a metabolite used as a biomarker of tobacco exposure, were completed. A paired-samples t-test was used to determine whether there was a statistically significant (p < 0.05) mean difference in biomarker levels before and after the program. Baseline and at 12-month follow-up data were available for 88 subjects, 21 of whom quit smoking entirely. Mean levels of solCD44 significantly decreased by 0.412 ng/mL from baseline to the 12-month follow-up, p = 0.010. There was no significant difference in mean TP levels, p = 0.975. Mean cotinine levels decreased significantly by 74.7 ng/mL, p = 0.035. This is the first work demonstrating an association between smoking cessation and decreased solCD44 levels in oral rinses. Decreased expression of the tumorigenic CD44 may be one mechanism by which smoking cessation lowers cancer risk.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74c50466c04c01d45a8878faa9bd50d https://doi.org/10.3390/ijerph182413174 Zobrazit plný text záznamu