Spinal deformities in deferoxamine-treated homozygous beta-thalassemia major patients
| Autor: | F. Olivieri, P. S. Babyn, M. J. Hartkamp |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Adolescent Thalassemia Deferoxamine medicine Humans Radiology Nuclear Medicine and imaging Child Intervertebral Disc Retrospective Studies Neuroradiology Dose-Response Relationship Drug business.industry Homozygote beta-Thalassemia Calcinosis Infant Retrospective cohort study medicine.disease Spine Vertebra Surgery Radiography medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Spinal Diseases Transfusion therapy sense organs business Complication medicine.drug Calcification |
| Zdroj: | Pediatric Radiology. 23:525-528 |
| ISSN: | 1432-1998 0301-0449 |
| Popis: | A new constellation of spinal changes are observed in homozygous beta-thalassemia major (HBT) patients receiving deferoxamine (DF), an iron-chelating drug used in combination with transfusion therapy in certain anemic syndromes. In a retrospective study of 22 HBT patients who were receiving DF therapy, morphological deformities (decreased spinal height, increased thoracic kyphosis, vertebral flattening and elongation anteriorly, and disk calcification) were found in 16 of 22 patients. These changes are believed to be caused by interference with spinal growth-plate development. Investigation of DF-dose correlation supports the conclusion that the spinal changes were DF-induced. Spinal changes observed in DF-treated patients differ both morphologically and pathogenetically from earlier reports of vertebral deformities occurring as a sequel to compensatory marrow hyperplasia in poorly transfused patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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