Real-Time Single-Cell Monitoring of Drug Effects Using Droplet-Based Microfluidic Technology: A Proof-of-Concept Study
| Autor: | Muge Kasim, Kutlu O. Ulgen, Elif Gencturk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
Cell growth Chemistry Microfluidics Cell Ribosome biogenesis Saccharomyces cerevisiae Computational biology Biochemistry Phenomics medicine.anatomical_structure Pharmaceutical Preparations Drug development Proof of concept Drug Discovery Genetics medicine Humans Molecular Medicine Personalized medicine business Molecular Biology Cell Proliferation Biotechnology |
| Zdroj: | OMICS: A Journal of Integrative Biology. 25:641-651 |
| ISSN: | 1557-8100 |
| Popis: | Drugs that act on ribosome biogenesis and cell proliferation play important roles in treatment of human diseases. Moreover, measurement of drug effects at a single-cell level would create vast opportunities for pharmaceutical innovation. We present in this study an original proof-of-concept study of single-cell measurement of drug effects with a focus on inhibition of ribosome biogenesis and cell proliferation, and using yeast ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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