Comparative Study on Trace Element Excretions between Nonanuric and Anuric Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

Autor: Wangqun Liang, Chenjiang Ying, Qiman Jin, Xuezhi Zuo, Ruiwei Meng, Siyun Xiang, Yunan Wan, Ying Yao, Nannan Wu, Fangyi Xu
Rok vydání: 2016
Předmět:
Male
medicine.medical_treatment
030232 urology & nephrology
continuous ambulatory peritoneal dialysis
Urine
030204 cardiovascular system & hematology
Gastroenterology
trace element
excretion
selenium
molybdenum
0302 clinical medicine
Peritoneal Dialysis
Continuous Ambulatory
Nutrition and Dietetics
medicine.diagnostic_test
Middle Aged
Treatment Outcome
Female
medicine.symptom
lcsh:Nutrition. Foods and food supply
Adult
medicine.medical_specialty
Urinalysis
Nutritional Status
chemistry.chemical_element
lcsh:TX341-641
Anuria
Article
Arsenic
Peritoneal dialysis
Excretion
Selenium
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Aged
Molybdenum
business.industry
Continuous ambulatory peritoneal dialysis
Trace Elements
Surgery
Cross-Sectional Studies
chemistry
Case-Control Studies
business
Biomarkers
Food Science
Zdroj: Nutrients
Nutrients, Vol 8, Iss 12, p 826 (2016)
Nutrients; Volume 8; Issue 12; Pages: 826
ISSN: 2072-6643
DOI: 10.3390/nu8120826
Popis: Few studies have been reported on alterations of trace elements (TE) in peritoneal dialysis patients. Our objective was to investigate and assess the characteristics of daily TE excretions in continuous ambulatory peritoneal dialysis (CAPD) patients. This cross-sectional study included 61 CAPD patients (nonanuric/anuric: 45/16) and 11 healthy subjects in Wuhan, China between 2013 and 2014. The dialysate and urine of patients and urine of healthy subjects were collected. The concentrations of copper (Cu), zinc (Zn), selenium (Se), molybdenum (Mo), and arsenic (As) in dialysate and urine were determined using inductively coupled plasma mass spectrometer (ICP-MS). Various clinical variables were obtained from automatic biochemical analyzer. Daily Cu, Zn, Se, and Mo excretions in nonanuric patients were higher than healthy subjects, while arsenic excretion in anuric patients was lower. A strong and positive correlation was observed between Se and Mo excretion in both dialysate (β = 0.869, p < 0.010) and urine (β = 0.968, p < 0.010). Furthermore, the clinical variables associated with Se excretion were found to be correlated with Mo excretion. Our findings indicated that nonanuric CAPD patients may suffer from deficiency of some essential TEs, while anuric patients are at risk of arsenic accumulation. A close association between Se and Mo excretion was also found.
Databáze: OpenAIRE
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