Echium Oil Reduces Plasma Triglycerides by Increasing Intravascular Lipolysis in apoB100-Only Low Density Lipoprotein (LDL) Receptor Knockout Mice
| Autor: | Lolita M. Forrest, Abraham K. Gebre, Soonkyu Chung, Thomas L. Smith, John S. Parks, Elena Boudyguina, Perry L. Colvin, Christopher M. Lough |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Very low-density lipoprotein Cholesterol VLDL Gene Expression 030204 cardiovascular system & hematology Palm Oil fish oil chemistry.chemical_compound Mice 0302 clinical medicine Echium Mice Knockout 0303 health sciences Lipoprotein lipase Nutrition and Dietetics very low density lipoproteins omega-3 fatty acids hepatic steatosis Fish oil n-3 fatty acids 3. Good health Biochemistry Liver botanical oil Low-density lipoprotein Apolipoprotein B-100 Cholesteryl ester Cholesterol Esters lcsh:Nutrition. Foods and food supply polyunsaturated fatty acids medicine.medical_specialty Lipolysis lcsh:TX341-641 Article 03 medical and health sciences Fish Oils Internal medicine medicine Animals Plant Oils Triglycerides 030304 developmental biology Cholesterol Mice Inbred C57BL Endocrinology chemistry Receptors LDL LDL receptor RNA PUFA Food Science |
| Zdroj: | Nutrients Volume 5 Issue 7 Pages 2629-2645 Nutrients, Vol 5, Iss 7, Pp 2629-2645 (2013) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu5072629 |
| Popis: | Echium oil (EO), which is enriched in SDA (18:4 n-3), reduces plasma triglyceride (TG) concentrations in humans and mice. We compared mechanisms by which EO and fish oil (FO) reduce plasma TG concentrations in mildly hypertriglyceridemic male apoB100-only LDLrKO mice. Mice were fed one of three atherogenic diets containing 0.2% cholesterol and palm oil (PO 20%), EO (10% EO + 10% PO), or FO (10% FO + 10% PO). Livers from PO- and EO-fed mice had similar TG and cholesteryl ester (CE) content, which was significantly higher than in FO-fed mice. Plasma TG secretion was reduced in FO vs. EO-fed mice. Plasma very low density lipoprotein (VLDL) particle size was ordered: PO (63 ± 4 nm) > EO (55 ± 3 nm) > FO (40 ± 2 nm). Post-heparin lipolytic activity was similar among groups, but TG hydrolysis by purified lipoprotein lipase was significantly greater for EO and FO VLDL compared to PO VLDL. Removal of VLDL tracer from plasma was marginally faster in EO vs. PO fed mice. Our results suggest that EO reduces plasma TG primarily through increased intravascular lipolysis of TG and VLDL clearance. Finally, EO may substitute for FO to reduce plasma TG concentrations, but not hepatic steatosis in this mouse model. |
| Databáze: | OpenAIRE |
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