Associations between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and coronary artery disease in a Tunisian population

Autor: Ali Bouslama, Lamia Rebhi, Asma Omezzine, Jihène Rejeb, Essia Boughzala, Nabila Ben Rejeb, Imen Boumaiza, Naoufel Nabli, R. Belkahla, Kaouthar Kchock, Ahmed Ben Abdelaziz
Rok vydání: 2010
Předmět:
Male
Polymorphismes d’ABCA1
Apolipoprotein B
Coronary Angiography
Coronary artery disease
Polymerase Chain Reaction
Severity of Illness Index
Linkage Disequilibrium
chemistry.chemical_compound
Gene Frequency
Risk Factors
Haplotype
Tunisian
Odds Ratio
Medicine
education.field_of_study
medicine.diagnostic_test
biology
Smoking
Reverse cholesterol transport
General Medicine
Middle Aged
Lipids
Phenotype
Female
lipids (amino acids
peptides
and proteins)
Cardiology and Cardiovascular Medicine
ATP Binding Cassette Transporter 1
medicine.medical_specialty
ABCA1 polymorphisms
Tunisia
Population
Black People
Polymorphism
Single Nucleotide
Risk Assessment
Tunisie
Diabetes Complications
Internal medicine
Humans
Genetic Predisposition to Disease
education
Allele frequency
Aged
Chi-Square Distribution
business.industry
Cholesterol
Coronary Stenosis
Odds ratio
Logistic Models
Endocrinology
Haplotypes
chemistry
Sténose coronaire
Case-Control Studies
ABCA1
biology.protein
ATP-Binding Cassette Transporters
business
Lipid profile
Zdroj: Archives of Cardiovascular Diseases. 103:530-537
ISSN: 1875-2136
DOI: 10.1016/j.acvd.2010.10.003
Popis: Summary Background The adenosine triphosphate-binding cassette transporter A1 (ABCA1) protein plays an important role in the first step of the reverse cholesterol transport system. Aims We studied the association of four polymorphisms in the ABCA1 gene (G1051A, G2706A, G2868A and –565C/T) with lipid profile and coronary artery disease. Methods Overall, 316 Tunisian patients underwent coronary angiography. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. Lipid and apolipoprotein concentrations were measured. Results Only carriers of the G2706A allele were associated with a decreased risk of significant stenosis (odds ratio [OR] 0.66, 95% confidence interval [CI] 0.22–0.92, p = 0.029), without pronounced effects on high-density lipoprotein (HDL) cholesterol. This protective effect was significant in smokers and diabetes. Carriers of the G1051A allele were associated only with increased concentrations of HDL cholesterol (p = 0.032). G2868A and –565C/T did not show any association with lipids or risk of significant stenosis. When ABCA1 polymorphisms were combined in haplotypes possessing G1051A, G2706A, G2868A and –565C/T, (AAGC) seemed to be most protective against significant stenosis (OR 0.5, 95% CI 0.29–0.96, p = 0.048) whereas (GGAT) was probably the most atherogenic (OR 1.26, 95% CI 1.03–1.56, p = 0.025). Conclusion Only the G2706A allele seems to be associated with a reduced risk of significant stenosis without important modification of HDL-cholesterol concentration, and appears to be more protective for smokers and diabetic patients. We found that (AAGC) seems to be a protective haplotype whereas (GGAT) has an atherogenic effect in a Tunisian population.
Databáze: OpenAIRE
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