Modulation of apoptosis of mononuclear cells under conditions of oxidative stress
| Autor: | O. B. Jukova, V. V. Novitsky, E. V. Kaygorodova, E. G. Starikova, N. V. Ryazantseva, Yu. V. Starikov, N. Yu. Chasovskih |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Apoptosis Pneumonia General Medicine Mitochondrion Biology medicine.disease_cause Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology In vitro Membrane Potentials Cell biology Oxidative Stress chemistry Receptors Tumor Necrosis Factor Type I Leukocytes Mononuclear medicine Humans Tumor necrosis factor alpha Reactive Oxygen Species Intracellular Oxidative stress |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 145:283-286 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-008-0071-0 |
| Popis: | We studied mitochondrial and type 1 tumor necrosis factor-a receptor (TNFR1)-mediated pathways triggering the apoptotic program in mononuclear cells under conditions of oxidative stress. Intensification of intracellular production of reactive oxygen forms is accompanied by an increase in the number of annexin-positive TNFRI-presenting cells and mononuclear cells with reduced mitochondrial transmembrane potential in case of induction of oxidative stress with 1 mM H2O2 in vitro and in patients with pneumonia. |
| Databáze: | OpenAIRE |
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