Cytotoxic Oxylipins from a Marine Sponge Topsentia sp
| Autor: | Kwang Sik Im, Chong-O. Lee, Jongki Hong, Jee H. Jung, Xuan Luo, Famei Li, Chung Ja Sim |
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| Rok vydání: | 2006 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Epoxide Antineoplastic Agents Fractionation Pharmacognosy Analytical Chemistry chemistry.chemical_compound Drug Discovery Animals Humans Cytotoxicity Pharmacology Korea Molecular Structure biology Chemistry Organic Chemistry Biological activity biology.organism_classification In vitro Porifera Sponge Complementary and alternative medicine Cyclization Fatty Acids Unsaturated Molecular Medicine Drug Screening Assays Antitumor Aliphatic compound |
| Zdroj: | Journal of Natural Products. 69:567-571 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np0503552 |
| Popis: | By a bioactivity-guided fractionation, seven new oxylipins, topsentolides A(1)-C(2) (1-7), were isolated from the MeOH extract of a marine sponge Topsentia sp. Detailed NMR and MS analyses established the planar structures of these structurally related oxylipins, which are proposed to be biosynthesized by lipoxygenation followed by cyclization of unsaturated fatty acids. Acetonide derivatives and MTPA esters were prepared to elucidate the stereochemistry of topsentolides B(1) (3), B(2) (4), and C(2) (7). All compounds were tested against a panel of five human solid tumor cell lines and displayed moderate cytotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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