Central administration of resistin promotes short-term satiety in rats
| Autor: | Rubén Nogueiras, Carlos Dieguez, Loraine Y.C. Tung, Suzanne L. Dickson, María Jesús Vázquez, Amanda C. Morris, Sulay Tovar, Lynda Williams, Tamara R. Castañeda |
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| Rok vydání: | 2005 |
| Předmět: |
Leptin
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Hypothalamus Adipose tissue Neuropeptide White adipose tissue Biology Satiety Response Energy homeostasis Statistics Nonparametric Eating Endocrinology Internal medicine medicine Animals Insulin Resistin RNA Messenger In Situ Hybridization Injections Intraventricular Body Weight General Medicine Immunohistochemistry Rats Taste Hormones Ectopic Intercellular Signaling Peptides and Proteins Ghrelin Adiponectin Proto-Oncogene Proteins c-fos hormones hormone substitutes and hormone antagonists |
| Zdroj: | European journal of endocrinology. 153(3) |
| ISSN: | 0804-4643 |
| Popis: | Objective: Several hormones expressed in white adipose tissue influence food intake at the central level. We sought to determine whether resistin, a circulating adipose-derived hormone in rodents, has actions on the hypothalamus by determining the effects of central resistin injection on food intake and on hypothalamic Fos protein expression. Design: As resistin expression in adipose tissue is influenced by altered nutritional status, we studied the effect of central resistin in both fed and pre-fasted rats. Results: In fasted rats, central injection of resistin decreased food intake acutely and increased the number of cells that express Fos protein in the arcuate nucleus but not in any other hypothalamic structure. The effect on food intake was dose-dependent and did not result in the formation of a conditioned taste aversion. Conclusions: Taken together, these results provide the first evidence documenting a central action of resistin, which could be involved in a feedback loop targeting the hypothalamus. On the other hand, since we observed resistin mRNA in the arcuate and ventromedial nuclei of the hypothalamus, it is also possible that brain-derived resistin serves as a neuropeptide involved in the regulation of energy homeostasis. However, since resistin-induced satiety was modest and transient, as central administration for several days did not affect body weight, the physiological relevance and therapeutic potential of the observed principal phenomenon may be limited. |
| Databáze: | OpenAIRE |
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