A Novel Tomato-Soy Juice Induces a Dose-Response Increase in Urinary and Plasma Phytochemical Biomarkers in Men with Prostate Cancer
| Autor: | Steven K. Clinton, Elizabeth Grainger, Robert R. Bahnson, Nancy E. Moran, Rachel E. Kopec, Ken M. Riedl, Jennifer M. Thomas-Ahner, Lei Wan, Gregory S. Young, David M. Francis, Steven J. Schwartz, Ronney Abaza |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Phytochemicals Medicine (miscellaneous) Genistein Pharmacology Beverages 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine Solanum lycopersicum Humans Medicine Original Research Article Aged 030109 nutrition & dietetics Nutrition and Dietetics business.industry Daidzein Prostate Prostatic Neoplasms food and beverages Glycitein Middle Aged Isoflavones medicine.disease Carotenoids Phytofluene Lycopene chemistry 030220 oncology & carcinogenesis Soybean Proteins Tomato-Soy Juice business Biomarkers |
| Zdroj: | The Journal of Nutrition. 149:26-35 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/nxy232 |
| Popis: | BACKGROUND: Tomato and soy intake is associated with reduced prostate cancer risk or severity in epidemiologic and experimental studies. OBJECTIVE: On the basis of the principle that multiple bioactives in tomato and soy may act on diverse anticancer pathways, we developed and characterized a tomato-soy juice for clinical trials. In this phase 2 dose-escalating study, we examined plasma, prostate, and urine biomarkers of carotenoid and isoflavone exposure. METHODS: Men scheduled for prostatectomy were recruited to consume 0, 1, or 2 cans of tomato-soy juice/d before surgery (mean ± SD duration: 24 ± 4.6 d). The juice provided 20.6 mg lycopene and 66 mg isoflavone aglycone equivalents/177-mL can. Plasma carotenoids and urinary isoflavone metabolites were quantified by HPLC–photometric diode array and prostate carotenoids and isoflavones by HPLC–tandem mass spectrometry. RESULTS: We documented significant dose-response increases (P |
| Databáze: | OpenAIRE |
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