The neonatal Fc receptor is expressed by human lymphocytes
| Autor: | J Bastiaans, S.G. Baarsma, W A Dik, E F De Haas, R W Kuipers, P M van Hagen, K van Bilsen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Medicine(all)
biology medicine.diagnostic_test Biochemistry Genetics and Molecular Biology(all) business.industry Endosome lcsh:R Cell lcsh:Medicine General Medicine General Biochemistry Genetics and Molecular Biology Immunoglobulin G Flow cytometry Cell biology Neonatal Fc receptor medicine.anatomical_structure Western blot Poster Presentation MHC class I Immunology biology.protein medicine Receptor business |
| Zdroj: | Journal of Translational Medicine, Vol 8, Iss Suppl 1, p P1 (2010) Journal of Translational Medicine |
| ISSN: | 1479-5876 |
| DOI: | 10.1186/1479-5876-8-s1-p1 |
| Popis: | The neonatal Fc receptor (FcRn) is an MHC class I like receptor that binds immunoglobulin G (IgG) in acidic environment (mainly endosomes). The FcRn protects IgG from lysosomal degradation, controls its transport between cell layers and extends IgG serum half-life [1]. It has been shown that the FcRn is expressed by many human cells including APCs and monocytes [2]. Thus far FcRn expression by human lymphocytes has not been proven. |
| Databáze: | OpenAIRE |
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