Experimental Study of the Effects of Permafrost Microorganisms on the Morphofunctional Activity of the Immune System
| Autor: | T. A. Fisher, J. A. Efimova, I. M. Besedin, Vladimir Melnikov, L. F. Kalenova, U. G. Suhovey, A. M. Subbotin, M. A. Novikova, A. V. Broushkov |
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| Rok vydání: | 2011 |
| Předmět: |
Microorganism
Cold climate Molecular Sequence Data Bacillus Cell Count Spleen Thymus Gland Biology Permafrost General Biochemistry Genetics and Molecular Biology Microbiology Mice Immune system Immunity RNA Ribosomal 16S Adrenal Glands medicine Animals Soil Microbiology Immunity Cellular Sequence Analysis DNA General Medicine Cold Climate Adaptation Physiological Immunity Humoral Siberia medicine.anatomical_structure Immune System Humoral immunity Immunology Mice Inbred CBA Functional activity |
| Zdroj: | ResearcherID |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The immunobiological potential of a new microorganism species isolated from permafrost specimens (PMO strain 3M) collected from the Mammoth Mountain in Yakutia was studied in laboratory mice. PMO injected intraperitoneally in doses of 2500 to 50 × 10(6) microbial bodies caused characteristic dose-dependent effects on the structure and functions of the immune system (thymus and spleen indexes, functional activity of splenic macrophages, cellular and humoral immunity). Doses of PMO stimulating functional activities of both cellular and humoral immunity were detected. |
| Databáze: | OpenAIRE |
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