Role of vitamin D‐calcium supplementation on metabolic profile and oxidative stress in gestational diabetes mellitus: A randomized controlled trial
Autor: | S Tahmina, Mary Daniel, Sunil Kumar Nanda, Preetha Gunasegaran |
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Rok vydání: | 2020 |
Předmět: |
Blood Glucose
Vitamin medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Calcium medicine.disease_cause law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Randomized controlled trial Pregnancy law Internal medicine medicine Vitamin D and neurology Humans Insulin Vitamin D 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Glutathione medicine.disease Gestational diabetes Diabetes Gestational Oxidative Stress Endocrinology Diabetic diet chemistry 030220 oncology & carcinogenesis Dietary Supplements Metabolome Female business Oxidative stress |
Zdroj: | Journal of Obstetrics and Gynaecology Research. 47:1016-1022 |
ISSN: | 1447-0756 1341-8076 |
Popis: | Aim To assess role of vitamin D-calcium supplementation on the metabolic profile and oxidative stress in women with Gestational Diabetes Mellitus (GDM) controlled on diet. Methods A randomized controlled trial was conducted at a tertiary care teaching hospital. Seventy women diagnosed as GDM at 24-28 weeks of gestation, controlled on a diabetic diet, were randomized to receive either vitamin D 1000 IU and calcium 1000 mg (group A, n = 34) or vitamin D 250 IU and calcium 500 mg (group B, n = 36) daily for 6 weeks. Levels of serum 25-hydroxy vitamin D, fasting plasma glucose (FPG), serum insulin, fasting lipid profile and total glutathione (GSH) were analyzed both prior to and after supplementation. Means, standard deviations and mean change were computed. Paired and independent t-tests were used to determine statistical significance between the two groups. Results Women in group A showed a significant reduction in FPG level (P-value = 0.007), fasting serum insulin level (P-value = 0.000), LDL (P-value = 0.000), total cholesterol levels (P-value = 0.000) and increase in HDL levels (P-value = 0.000). Group B had a significant fall only in FPG after 6 weeks supplementation. A significant change in total glutathione level (P-value = 0.000) was observed in both groups. Conclusion Vitamin D and calcium supplementation at a dose of 1000 IU and 1000 mg, respectively, has a beneficial role in glucose metabolism, lipid metabolism and oxidative stress in GDM. |
Databáze: | OpenAIRE |
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