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OBJECTIVE: To report C-reactive protein (CRP) following Roux-en-Y gastric bypass surgery (RYGB). BACKGROUND: Long-term change in CRP is not well characterized in the context of Roux-en-Y gastric bypass (RYGB). METHODS: Between 2006–2009, 1770 adults enrolled in a US multi-center prospective cohort study (Longitudinal Assessment of Bariatric Surgery) underwent RYGB. Research assessments were conducted pre-surgery and annually post-surgery up to 7 years. This study included those with high-sensitivity CRP assessed pre-surgery and one or more follow up assessments (n=1180). RESULTS: Pre-surgery, participants’ median age was 46 years and median body mass index (BMI) was 46 kg/m(2); 80% were female. At pre-surgery, mean (95% CI) CRP (mg/L) was the highest of all time points (1.01 [0.95–1.08]); it then decreased to a nadir of 0.18 (0.15–0.22) at 2 years post-surgery (P1 mg/dL) 7 years post-surgery versus 32.9% (95% CI, 30.2–35.3) pre-surgery (P |
