Relationships between fasting plasma insulin, anthropometrics, and metabolic parameters in a very old healthy population
Autor: | M. Carantoni, E. Palmieri, L. Vergnani, Stefano Volpato, R. Fellin, Giovanni Zuliani, Andrea Mezzetti |
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Jazyk: | angličtina |
Rok vydání: | 1998 |
Předmět: |
ANTHROPOMETRICS
medicine.medical_specialty ELDERLY business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment INSULIN METABOLISM medicine.disease Fibrinogen Endocrinology Waist–hip ratio Insulin resistance Internal medicine Blood plasma medicine Hyperinsulinemia Metabolic syndrome business Pancreatic hormone medicine.drug |
Popis: | Several studies have shown that insulin resistance and hyperinsulinemia are associated with many metabolic disorders predisposing to coronary heart disease (CHD). This syndrome has been termed syndrome X. However, it is not completely known whether these relationships are still present in the elderly, or whether other factors such as age, gender, and body fat distribution modulate them. Therefore, we investigated the relationship between fasting plasma insulin, total and regional adiposity, fasting plasma glucose and lipids, plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and coagulation factor VII in a sample of 100 healthy free-living octogenarians-nonagenarians (52 men and 48 women) who were disability-free according to the Katz index. By univariate analysis, fasting insulin correlated positively with all anthropometric measures except the waist to hip ratio (WHR) in women. There was a positive correlation between fasting insulin and fasting glucose ( r = .40, P r = .21, P r = .33, P r = −.22 and r = −.24, respectively, P R 2 = .14), while gender and fasting insulin were the best predictors of HDL-C variance ( R 2 = .17). Furthermore, fasting insulin was the only variable independently related to PAI-1 ( R 2 = .12). Our findings support the existence of a metabolic syndrome even in very old age by showing that high insulin levels are related to various metabolic and hemostatic disorders. |
Databáze: | OpenAIRE |
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