Positive fluid balance is associated with death and severity of brain injury in neonates with hypoxic-ischemic encephalopathy
| Autor: | Nicole Herrera, Gilbert Vezina, Suleiman Mashat, An N. Massaro, Michelande Ridore, Sudeepta K Basu, Taeun Chang, Katherine M. Ottolini, James E. Bost, Vedavalli Govindan |
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| Rok vydání: | 2020 |
| Předmět: |
Encephalopathy
Logistic regression Hypoxic Ischemic Encephalopathy 03 medical and health sciences 0302 clinical medicine Positive fluid balance 030225 pediatrics Secondary analysis medicine Humans 030212 general & internal medicine Balance (ability) medicine.diagnostic_test business.industry Infant Newborn Obstetrics and Gynecology Magnetic resonance imaging Hypothermia Water-Electrolyte Balance medicine.disease Anesthesia Brain Injuries Pediatrics Perinatology and Child Health Hypoxia-Ischemia Brain medicine.symptom business |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association. 41(6) |
| ISSN: | 1476-5543 |
| Popis: | To investigate the association between fluid balance during therapeutic hypothermia (TH) and severity of brain injury on magnetic resonance imaging (MRI) in neonates with hypoxic-ischemic encephalopathy (HIE).This is a secondary analysis of data from a prospective observational study in neonates with HIE. Daily net positive fluid balance during TH was investigated for association with the adverse primary outcome of death or moderate-to-severe brain injury on MRI using multivariable logistic regression.Of the 150 neonates included, 50 suffered adverse outcome and had significantly higher net positive fluid balance (53 vs. 19 ml/kg/day, p 0.01) during first 24 hours of TH. Neonates with a net positive fluid balance (25 ml/kg/day) at 24 hours of TH had 3.4 (95% CI 1.3-9) times higher odds of adverse outcome.Positive fluid balance during TH in neonates with HIE is independently associated with death or moderate-to-severe brain injury on MRI. |
| Databáze: | OpenAIRE |
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