Zonulin, inflammation and iron status in patients with early stages of chronic kidney disease
| Autor: | Jolanta Malyszko, Ewelina Lukaszyk, Ewa Koc-Zorawska, Mateusz Lukaszyk, Anna Bodzenta-Lukaszyk |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Cholera Toxin Anemia Urology Iron 030232 urology & nephrology Hepcidin Gastroenterology 03 medical and health sciences 0302 clinical medicine Hepcidins Diabetes mellitus Internal medicine Chronic kidney disease Receptors Transferrin medicine Nephrology - Original Paper Humans Protein Precursors Renal Insufficiency Chronic Soluble transferrin receptor Aged Inflammation Aged 80 and over Intestinal permeability biology Haptoglobins business.industry Interleukin-6 Zonulin Middle Aged medicine.disease Ferritin 030104 developmental biology C-Reactive Protein Nephrology Case-Control Studies biology.protein business Biomarkers Kidney disease |
| Zdroj: | International Urology and Nephrology |
| ISSN: | 1573-2584 0301-1623 |
| Popis: | Background/aims Zonulin is the only known regulator of intestinal permeability. It is also considered as a potential inflammatory marker in several conditions such as diabetes and inflammatory bowel syndrome. The aim of the study was to investigate zonulin levels in patients with early stages of CKD and its possible correlation with inflammation, anemia and iron status parameters. Methods Eighty-eight patients with early stages of CKD and 23 healthy volunteers were enrolled in the study. Zonulin, hepcidin-25, soluble transferrin receptor, interleukin-6 and high-sensitivity C-reactive protein were measured using commercially available assays. Results Zonulin was significantly lower among patients with CKD in comparison with healthy volunteers. There were no statistically significant differences in zonulin concentration between patients with and without inflammation. Zonulin was significantly correlated with hepcidin only in patients with inflammation. Zonulin was neither related to iron nor related to ferritin. Conclusions Zonulin cannot be considered as an inflammatory marker in CKD. It does not play a role in the disturbances of iron metabolism in CKD. Its physiological role remains to be elucidated. |
| Databáze: | OpenAIRE |
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