Constipation Predicts Cognitive Decline in Parkinson's Disease: Results from the COPPADIS Cohort at 2-Year Follow-up and Comparison with a Control Group
| Autor: | Marina Cosgaya, Jose M. Paz González, Esther Cubo, Maria G. Alonso Losada, Nuria López Ariztegui, Isabel González Aramburu, Carmen Borrué, Lydia López Manzanares, Jaime Kulisevsky, Iria Cabo, Julio Dotor García-Soto, Pau Pastor, Carlos Cores Bartolomé, Nuria Caballol, Jessica González Ardura, Lucía García Roca, Berta Solano Vila, Luis M. López Díaz L, Víctor Puente, Pablo Martinez-Martin, Juan García Caldentey, Javier Rúiz Martínez, Lydia Vela, Cristina Martínez Miró, Itziar Gastón, Lucía Naya Ríos, Francisco Carrillo Padilla, Ruben Alonso Redondo, Darrian McAfee, Juan C. Martínez Castrillo, Ines Legarda, Silvia Jesús, Carlos Ordás, Víctor Nogueira, Marta Blázquez Estrada, Oriol de Fábregues, Miquel Aguilar, Hector Canfield, Manuel Seijo, Teresa de Deus Fonticoba, Jorge Hernández Vara, Maria A. Ávila Rivera, Pablo Mir, Pilar Sánchez Alonso, Diego Santos García, Lluis Planellas, Caridad Valero, Monica M. Kurtis, Víctor Gómez Mayordomo, Sonia Escalante, María Álvarez Sauco |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
impairment Constipation Parkinson's disease Non-motor symptoms Disease Cellular and Molecular Neuroscience Cognition Rating scale Internal medicine Cognitive Changes Medicine Humans Cognitive Dysfunction Cognitive decline business.industry Parkinson Disease constipation medicine.disease Control Groups non-motor symptoms Impairment Cohort Parkinson’s disease Neurology (clinical) medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of Parkinsons Disease r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1877-7171 |
| Popis: | [Background] Constipation has been linked to cognitive impairment development in Parkinson’s disease (PD). Objective:Our aim was to analyze cognitive changes observed in PD patients and controls from a Spanish cohort with regards to the presence or not of constipation. Methods:PD patients and controls recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017 were followed-up during 2 years. The change in cognitive status from baseline (V0) to 2-year follow-up was assessed with the PD-CRS (Parkinson’s Disease Cognitive Rating Scale). Subjects with a score ≥1 on item 21 of the NMSS (Non-Motor Symptoms Scale) at baseline (V0) were considered as “with constipation”. Regression analyses were applied for determining the contribution of constipation in cognitive changes. [Results] At V0, 39.7% (198/499) of PD patients presented constipation compared to 11.4% of controls (14/123) (p [Conclusion] Constipation is associated with cognitive decline in PD patients but not in controls. |
| Databáze: | OpenAIRE |
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