Induction of OX40, a Receptor of gp34, on T Cells by Trans-acting Transcriptional Activator, Tax, of Human T-Cell Leukemia Virus Type I
| Autor: | Naruhiko Takasawa, Norikazu Higashimura, Yuetsu Tanaka, Kazuo Sugamura, Masataka Nakamura |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Gene Expression Regulation
Viral Transcriptional Activation Cancer Research T-Lymphocytes Tax OX40 Ligand Biology Receptors Tumor Necrosis Factor Cadmium Chloride Chlorides Tumor Cells Cultured medicine Humans Leukemia-Lymphoma Adult T-Cell OX40 IL-2 receptor education Receptor health care economics and organizations Human T-lymphotropic virus 1 education.field_of_study Membrane Glycoproteins HTLV‐I Gene Expression Regulation Leukemic Cell growth ZAP70 Gene Products tax T lymphocyte Receptors OX40 medicine.disease Virology Neoplasm Proteins Tumor Necrosis Factor Receptor Superfamily Member 7 OX40 ligand Cell biology Leukemia Oncology Culture Media Conditioned Trans-acting Rapid Communication Cadmium |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| DOI: | 10.1111/j.1349-7006.1996.tb00210.x |
| Popis: | gp34, which we had identified as a target molecule of the trans‐activation by Tax of human T‐cell leukemia virus type I (HTLV‐I), has been found to bind OX40, a member of the tumor necrosis factor receptor family, resulting in growth stimulation of activated T cells. We here demonstrate that not only gp34 (OX40L), but also OX40 can be transcriptionally activated by Tax. Three Tax‐producing human T‐cell lines carrying the HTLV‐I genome expressed OX40 on their surfaces. Furthermore, Tax‐induced transcriptional activation of OX40 was shown in Tax‐inducible JPX‐9 cells. These results demonstrate that both OX40 and its ligand (gp34) are constitutively expressed on the surfaces of Tax‐expressing T lymphocytes, suggesting that the OX40L/OX40 system contributes to growth stimulation of the virus‐infected T cells. |
| Databáze: | OpenAIRE |
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