Approach to critical illness myopathy and polyneuropathy in the older SARS-CoV-2 patients

Autor: Ricci Kalayanamitra, Brendan McClafferty, Gary Fye, Alice Cai, Rohit Jain, Dhirisha Bhatt, Chander Shekher Aggarwal, Andrew Groff, Abani Bhandari, Ravi Patel, Devyani Ramgobin, Ashutosh Kumar, Ramarao Vunnam, Reshma Golamari, Ibrahim Umer, Douglas Kepko, Zainab Shahid, Hyma Polimera, Nitasa Sahu
Rok vydání: 2020
Předmět:
Critical Illness Myopathy
(IL-6)
Interleukin-6
medicine.medical_treatment
Older Adults
SAA1
serum amyloid A1
0302 clinical medicine
Risk Factors
Health care
Pandemic
CIM
Critical illness myopathy
Critical illness polyneuropathy
CIPNM
critical illness polyneuromyopathy
Incidence (epidemiology)
CIP
critical illness polyneuropathy
General Medicine
Critical Illness Polyneuropathy
Neurology
030220 oncology & carcinogenesis
Coronavirus Infections
Polyneuropathy
Intensive Care Unit-acquired Weakness
medicine.medical_specialty
ICUAW
ICU-acquired weakness
Critical Illness
Pneumonia
Viral
Clinical Neurology
Article
Betacoronavirus
Polyneuropathies
03 medical and health sciences
Muscular Diseases
Physiology (medical)
Intensive care
medicine
Animals
Humans
Intensive care medicine
Pandemics
ARDS
acute respiratory distress syndrome
ANM
acute necrotizing myopathy
Mechanical ventilation
SARS-CoV-2
business.industry
PCIS
post intensive care syndrome
COVID-19
medicine.disease
Respiration
Artificial
body regions
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Journal of Clinical Neuroscience
ISSN: 0967-5868
DOI: 10.1016/j.jocn.2020.07.058
Popis: Highlights • Critical illness myopathy/neuropathy often go under-diagnosed. • Over 70% of patients hospitalized for SARS-CoV-2 were ≥50 years old. • Older populations are at higher risk of suffering from ICU acquired weakness. • Early mobilization is a mainstay of treatment for ICU acquired weakness.
One of the major concerns of the health care community and the public surrounding the SARS-CoV-2 pandemic is the availability and use of ventilators. Unprecedented surges of patients presented to intensive care units across the country, with older adults making up a large proportion of the patient population. This paper illustrates contemporary approaches to critical illness myopathy (CIM), critical illness polyneuropathy (CIP), and critical illness polyneuromyopathy (CIPNM) in older patients, including incidence, risk factors, mechanisms for pathology, diagnosis, contemporary treatment approaches, and outcomes. We hope that the following analysis may help educate clinicians and ultimately decrease the duration of the mechanical ventilation required by these patients, resulting in improved clinical outcomes and an increase in ventilator availability for other patients in need.
Databáze: OpenAIRE
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