Gut Microbiota and the Alteration of Immune Balance in Skin Diseases: From Nutraceuticals to Fecal Transplantation
| Autor: | Aleksandra Vojvodic, Nenad Stepic, Torello Lotti, Mohamad Goldust, Goran Sijan, Sanja Dimitrijevic, Badr Abdulwahab E Badr, Massimo Fioranelli, Michael Tirant, Dusica Matovic, Petar Vojvodic, Uwe Wollina, Tatjana Vlaskovic-Jovicevic, Van Thuong Nguyen, Zorica Peric-Hajzler, Ashraf Badawi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medicine
030209 endocrinology & metabolism Review Article inflammatory Gut flora immunology 03 medical and health sciences Therapeutic approach 0302 clinical medicine Nutraceutical Immune system microbiota Medicine 030212 general & internal medicine biology treatment business.industry lcsh:R General Medicine Fecal bacteriotherapy biology.organism_classification Pathophysiology cytokines Transplantation skin diseases Immunology business Homeostasis |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences; Vol 7 No 18 (2019): Sep 30 (Global Dermatology); 3034-3038 Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences, Vol 7, Iss 18 (2019) |
| ISSN: | 1857-9655 3034-3038 |
| Popis: | T The P.N.E.I. (Psycho-Neuro-Endocrine-Immunology) approach is represented by the interdisciplinary concept of bidirectional cross-talk between the psycho-neuro-endocrine and immune systems, which can influence the immune response. The well-known Gut-Brain Axis and the Gut-Skin Axis can be merged in a bigger network- the Gut-Brain-Skin Axis, with complex regulation by cytokines, neuro-peptides, neuro-hormones and another messenger (signalling) molecules and maybe the most important modulator of the Gut-Brain-Skin Axis/ the gut microbiota. The role of gut bacterial homeostasis is very important, and the homeostatic imbalance of the immune response may be a relevant etiologic/pathophysiologic factor for extra-intestinal and intestinal inflammatory, allergic and autoimmune diseases. The Low Dose Cytokines Medicine (LDM) is an innovative therapeutic approach. It is based on the most advanced knowledge in molecular biology and low dose pharmacology with the primary outcome. The SKA (Sequential Kinetic Activation) technology, codified and standardised by GUNA S.p.a. -Italy- makes the low doses of signalling molecules able to be active even below the minimum dose classically considered as effective and the significative efficacy of orally administered low-dose signalling molecules is the most representative aspect of LDM. The Physiologic Nutraceuticals and the Low Dose Medicine are two of the most promising approaches for the treatment of skin diseases based on the rebalance of the immune response and the recovery of gut dysbiosis. |
| Databáze: | OpenAIRE |
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