Alterations in the Development of Rat Cerebellum and Impaired Behavior of Juvenile Rats after Neonatal 6-OHDA Treatment
| Autor: | I. Djatchkova-Podkletnova, H. Alho |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Cerebellum In situ hybridization Biology Biochemistry Rats Sprague-Dawley Cellular and Molecular Neuroscience Internal medicine medicine Animals Neurotoxin RNA Messenger Oxidopamine Behavior Animal GABAA receptor Neurotoxicity General Medicine Receptors GABA-A medicine.disease Immunohistochemistry Rats Motor coordination Microscopy Electron Endocrinology medicine.anatomical_structure Animals Newborn nervous system Systemic administration Neuroglia Neuroscience |
| Zdroj: | Neurochemical Research. 30:1599-1605 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-005-8838-4 |
| Popis: | The effects of neonatal systemic administration of the neurotoxin 6-hydroxydopamine (6-OHDA) on cerebellum development and behavior were studied in juvenile rats. The methods employed were immunohistochemistry, in situ hybridization, ligand binding, and behavioral testing. The results revealed, for the first time, that 6-OHDA treatment alters Bergmann glial cells and reduced the expression GABAA receptor subtypes alpha1 and alpha6 especially in granule cells. The Bergmann glial cells were abnormally located and structurally different (e.g., no intimate associations with Purkinje cells). Significant microglial activation was also observed. The animals showed impairment in behavior, especially in their orientation to a novel environment. Recent data on neuron-glia interactions support the conclusion that the observed structural changes in Bergmann glia and granular neurons disrupted the normal functioning of the Purkinje cells which then in turn resulted in the impaired sensory-motor coordination at least in juvenile rats. This paper is a summary of previously published work and some recent data in this field obtained at our laboratory. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink