Identifying patients with rheumatoid arthritis with moderate disease activity at risk of significant radiographic progression despite methotrexate treatment
| Autor: | Y Brault, G Gallo, H W Nab, B Fautrel |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology Multivariate analysis Radiography Immunology Population Rheumatoid Arthritis environment and public health Gastroenterology Etanercept Rheumatology Internal medicine medicine Immunology and Allergy Rheumatoid factor education education.field_of_study biology business.industry C-reactive protein medicine.disease Treatment Methotrexate Rheumatoid arthritis biology.protein DMARDs (synthetic) business medicine.drug |
| Zdroj: | RMD Open |
| ISSN: | 2056-5933 |
| DOI: | 10.1136/rmdopen-2014-000018 |
| Popis: | Objectives To determine the baseline factors predictive of significant radiographic progression (SRP) in patients with moderately active rheumatoid arthritis (RA) despite receiving methotrexate (MTX). Methods Patients from the MTX arm of the Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes (TEMPO) trial with sustained moderate RA (defined as ≥3.2 mean disease activity score in 28 joints ≤5.1 during the last 6 months of the first year) were analysed for SRP (mTSS >3.0 overall) after 2 and 3 years. Baseline predictors for SRP were identified by univariate and multivariate analyses. All variables shown to be significantly associated with SRP were categorised based on clinically relevant cut-offs and tertiles and were included in a matrix risk model. Results 228 patients were assigned MTX treatment, 210 patients were in the radiographic intention-to-treat population, and 96 of these had sustained moderate RA. SRP occurred in 25 (26%) and 33 (34%) patients after 2 and 3 years of MTX treatment, respectively. Univariate and multivariate analyses found that C reactive protein (CRP) and rheumatoid factor (RF) positivity at baseline were predictive of SRP after 2 and 3 years (p40 mg/L at baseline were significantly associated with SRP after 2 (p |
| Databáze: | OpenAIRE |
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