In vitroactivity of compounds isolated fromPiper crassinerviumagainstTrypanosoma cruzi
| Autor: | Silvia N. Lopez, Vanderlan da Silva Bolzani, Daniela Luz Ambrósio, João Marcos Batista Junior, Luis Octávio Regasini, Maysa Furlan, Adriana A. Lopes, Massuo J. Kato, Regina Maria Barretto Cicarelli |
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| Rok vydání: | 2008 |
| Předmět: |
Chagas disease
Stereochemistry Trypanosoma cruzi Plant Science Biochemistry Analytical Chemistry chemistry.chemical_compound medicine Animals Benzoic acid Hydroquinone biology Plant Extracts Organic Chemistry TRYPANOSOMA CRUZI Piperaceae biology.organism_classification medicine.disease Trypanocidal Agents In vitro chemistry Benznidazole Piper Flavanone medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786410802243271 |
| Popis: | This study describes the antichagasic potential of five compounds isolated from leaves of Piper crassinervium (Piperaceae). Two prenylated benzoic acid derivatives, one prenylated hydroquinone and two flavanones, were evaluated. The in vitro trypanocidal activity was determined against epimastigote forms of Trypanosoma cruzi (Y strain), the etiologic agent of Chagas disease. The most active compound was the prenylated hydroquinone [1,4-dihydroxy-2-(3(0),7(0)-dimethyl-1(0)-oxo-2(0)-E,6(0)-octadienyl)benzene] with an IC(50) value of 6.10 microg mL(-1), which was in the same order of activity if compared with the positive control benznidazole (IC(50) = 1.60 microg mL(-1)). This is the first report of trypanocidal activity for prenylated hydroquinone and benzoic acid derivatives. |
| Databáze: | OpenAIRE |
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