Propofol versus combined sedation in flexible bronchoscopy: a randomised non-inferiority trial
| Autor: | Daiana Stolz, E Pflimlin, Anja Meyer, Michael Tamm, Werner Strobel, Prashant N. Chhajed, Gabriel Kurer |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Midazolam Sedation law.invention Randomized controlled trial Bronchoscopy law medicine Humans Hydrocodone Infusions Intravenous Propofol Aged Aged 80 and over medicine.diagnostic_test business.industry Middle Aged Endoscopy Surgery Oxygen Treatment Outcome Respiratory failure Anesthesia Female medicine.symptom business Anesthetics Intravenous medicine.drug |
| Zdroj: | European Respiratory Journal. 34:1024-1030 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.00180808 |
| Popis: | Combined sedation with a benzodiazepine and an opiate has been proposed as standard sedation for bronchoscopy. Propofol is a sedative-hypnotic with a rapid onset of action and fast recovery time, but carries the potential risk of respiratory failure. Consecutive patients (n = 200) were randomly allocated to receive either the combination midazolam and hydrocodone or intravenous propofol. The primary end-points were the mean lowest arterial oxygen saturation during bronchoscopy and the readiness-for-discharge score 1 h after the procedure. The mean lowest arterial oxygen saturation during bronchoscopy did not differ across treatment groups (p = 0.422), and the number of patients recording an arterial oxygen saturation ofor =90% on at least one occasion was similar in both groups (p = 0.273). The median (interquartile range) readiness-for-discharge score 1 h after the procedure was significantly higher in the propofol group than in the combined sedation group (8 (6-9) versus 7 (5-9); p = 0.035). Patients assigned propofol exhibited less tachycardia during bronchoscopy and foror =1 h after the examination. Minor procedural complications were noted in 71 (35.5%) patients and exhibited a similar incidence in both treatment arms (p = 0.460). Propofol is as effective and safe as combined sedation in patients undergoing flexible bronchoscopy, thus representing an appealing option if timely discharge is a priority. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|