Prediction of the minimum spacer thickness required for definitive radiotherapy with carbon ions and photons for pelvic tumors: an in silico planning study using virtual spacers
| Autor: | Yasuhito Hagiwara, Shohei Kawashiro, Takayuki Kanai, Hikaru Souda, Yuya Miyasaka, Kenji Nemoto, Mayumi Ichikawa, Mayumi Harada, Hiroko Akamatsu, Masayoshi Yamada, Natsuko Yano, Rei Matsueda, Hiraku Sato, Ken Uematsu |
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| Rok vydání: | 2021 |
| Předmět: |
Photon
Health Toxicology and Mutagenesis medicine.medical_treatment Planning target volume carbon-ion radiotherapy (C-ion RT) Oncology/Medicine 030218 nuclear medicine & medical imaging planning study 03 medical and health sciences 0302 clinical medicine Planning study Linear regression medicine spacer Radiology Nuclear Medicine and imaging intensity-modulated radiotherapy (IMRT) Definitive radiotherapy Physics Radiation business.industry Minimum distance medicine.disease Radiation therapy in silico 030220 oncology & carcinogenesis AcademicSubjects/SCI00960 Pelvic tumor AcademicSubjects/MED00870 Nuclear medicine business |
| Zdroj: | Journal of Radiation Research |
| ISSN: | 1349-9157 0449-3060 |
| DOI: | 10.1093/jrr/rrab047 |
| Popis: | We aimed to predict the minimum distance between a tumor and the gastrointestinal (GI) tract that can satisfy the dose constraint by creating simulation plans with carbon-ion (C-ion) radiotherapy (RT) and photon RT for each case assuming insertion of virtual spacers of various thicknesses. We enrolled 55 patients with a pelvic tumor adjacent to the GI tract. Virtual spacers were defined as the overlap volume between the GI tract and the volume expanded 7–17 mm from the gross tumor volume (GTV). Simulation plans (70 Gy in 35 fractions for at least 95% of the planning target volume [PTV]) were created with the lowest possible dose to the GI tract under conditions that meet the dose constraints of the PTV. We defined the minimum thickness of virtual spacers meeting D2 cc of the GI tract |
| Databáze: | OpenAIRE |
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