Prevalence of elevated glycated hemoglobin concentrations in the polycystic ovary syndrome: anthropometrical and metabolic relationship in amazonian women
| Autor: | Márcia Marly Winck Yamamoto, Herica Bernardes Bueno, Jacklyne Silva Barbosa, Sebastião Freitas de Medeiros, Danilla Belizario |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Waist Triglyceride endocrine system diseases business.industry Free androgen index medicine.drug_class nutritional and metabolic diseases Impaired glucose tolerance General Medicine medicine.disease Androgen Polycystic ovary chemistry.chemical_compound Endocrinology Glycated hemoglobin chemistry Internal medicine Medicine Original Article business Body mass index Polycystic ovary syndrome |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3003 |
| Popis: | Background: To determine the prevalence of elevated glycated hemoglobin (HbA1c) and to examine its relationship with other carbohydrate metabolic parameter among Brazilian women with polycystic ovary syndrome (PCOS). Methods: A cross-sectional study including 288 PCOS patients was conducted. Anthropometrical, clinical, biochemical and endocrine parameters were evaluated. Results: The mean age was 26.92 ± 5.51 years. HbA1c mean concentration was 5.83±1.34%. In 38.54% of patients, HbA1c was ≥ 5.7%. HbA1c was positively correlated with body weight (r = 0.142, P = 0.017), body mass index (P = 0.000), waist:hip ratio (P = 0.000), fat mass (P = 0.000), conicity index (P = 0.000), triglyceride (P = 0.001), C-peptide (P = 0.000), total testosterone (P = 0.003), free testosterone (P = 0.000), free androgen index (P = 0.006) and fasting insulin (P = 0.025). Using the oral glucose tolerance test, HbA1c showed positive correlation with glucose concentrations at any point in time (P < 0.05). Conclusions: HbA1c was elevated in nearly 40% of PCOS patients and it showed positive correlation with several anthropometric and metabolic factors and androgen levels. The current study provides further evidence that HbA1C is higher in PCOS patients and may have a potential role in the prediction of dysglycemic disease in these women. |
| Databáze: | OpenAIRE |
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