Calibration of Baroreflex Equilibrium Diagram Based on Exogenous Pressor Agents in Chronic Heart Failure Rats
| Autor: | Michael J. Turner, Can Zheng, Masaru Sugimachi, Meihua Li, Shuji Shimizu, Toru Kawada, Yusuke Sata |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system Equilibrium diagram NC ratio Baroreflex norepinephrine Norepinephrine (medication) Internal medicine medicine cardiovascular diseases carotid sinus baroreflex Phenylephrine Original Research business.industry Sympathetic nerve activity open-loop analysis medicine.disease phenylephrine body regions Blood pressure lcsh:RC666-701 Heart failure Cardiology arterial pressure Cardiology and Cardiovascular Medicine business medicine.drug Biomedical engineering circulatory and respiratory physiology |
| Zdroj: | Clinical Medicine Insights: Cardiology, Vol 9s1 (2015) Clinical Medicine Insights. Cardiology Clinical Medicine Insights: Cardiology, Vol 2015, Iss Suppl. 1, Pp 1-9 (2015) |
| ISSN: | 1179-5468 |
| Popis: | A baroreflex equilibrium diagram describes the relation between input pressure and sympathetic nerve activity (SNA) and that between SNA and arterial pressure (AP). To calibrate the SNA axis (abscissa) of the baroreflex equilibrium diagram, the AP response to intravenous bolus injections of phenylephrine (0.2-50 μg/kg) or norepinephrine (NE, 0.02-5 μg/kg) was examined in normal control rats (NC, n = 9) and rats with chronic heart failure (CHF, n = 6). The maximum slope of the dose–effect curve was significantly smaller in the CHF group than in the NC group (57.3 ± 5.2 vs 80.9 ± 6.3 mmHg/decade for phenylephrine, 60.2 ± 7.8 vs 80.4 ± 5.9 mmHg/decade for NE; P < 0.01). The CHF/NC ratio of the maximum slope was used to calibrate SNA. While the calibrated baroreflex equilibrium diagram showed increased maximum SNA and operating-point SNA in CHF rats compared with NC rats, the magnitude of increase was smaller than that expected from the excess plasma NE concentration in CHF rats. Plasma NE concentration in the CHF group could be disproportionally high relative to SNA. |
| Databáze: | OpenAIRE |
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