Infusion hemolysis after pediatric major ABO-mismatched bone marrow transplant: Comparison of two red blood cell depletion techniques
| Autor: | Robert Sheppard Nickel, Kuang-Yueh Chiang, Diana Worthington-White, Muna Qayed, Sean R. Stowell |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Urology Ficoll Cell Separation 030204 cardiovascular system & hematology Hydroxyethyl starch Hemolysis Article ABO Blood-Group System Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine hemic and lymphatic diseases ABO blood group system medicine Humans Child reproductive and urinary physiology Bone Marrow Transplantation Retrospective Studies Creatinine business.industry Hematology medicine.disease Surgery Red blood cell medicine.anatomical_structure Oncology chemistry Blood Group Incompatibility Pediatrics Perinatology and Child Health Female Hemoglobinuria Bone marrow biological phenomena cell phenomena and immunity business 030215 immunology medicine.drug |
| Zdroj: | Pediatric Blood & Cancer. 65:e26883 |
| ISSN: | 1545-5009 |
| DOI: | 10.1002/pbc.26883 |
| Popis: | Background During major ABO-mismatched bone marrow transplant (BMT), the infusion of incompatible red blood cells (RBCs) that are present in the bone marrow graft can cause adverse events from hemolysis. RBC depletion of the bone marrow graft can decrease this risk, but the optimal method to prevent hemolysis is unclear. Procedure We conducted a retrospective cohort study of patients who underwent major ABO-mismatched BMT at a pediatric center and had RBC depletion with either hydroxyethyl starch (HES) sedimentation or Ficoll density gradient separation. Postinfusion hemoglobinuria and creatinine values were compared. Results Between 2002 and 2016, 37 patients received HES-treated and 16 patients received Ficoll-treated major ABO-mismatched bone marrow grafts. The median residual volume of RBCs was significantly greater with HES-treated grafts (HES 21.0 ml vs. Ficoll 1.4 ml, P |
| Databáze: | OpenAIRE |
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