Clonal relationship and the association of the ST218 strain harboring blaOXA-72 gene to mortality in carbapenem-resistant Acinetobacter baumannii bacteremia
Autor: | Tainyi Luor, Hsi-Peng Lu, Chang-Pan Liu |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Microbiology (medical) General Immunology and Microbiology Molecular epidemiology Transmission (medicine) 030106 microbiology lcsh:QR1-502 Virulence General Medicine Odds ratio Biology medicine.disease biology.organism_classification lcsh:Microbiology Microbiology Acinetobacter baumannii 03 medical and health sciences 0302 clinical medicine Infectious Diseases Bacteremia Pulsed-field gel electrophoresis medicine Immunology and Allergy 030212 general & internal medicine Gene |
Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 52, Iss 2, Pp 297-303 (2019) |
ISSN: | 1684-1182 |
Popis: | Background/purpose: In 2017, the World Health Organization categorized carbapenem-resistant Acinetobacter baumannii (CRAB) as a priority 1, critical antibiotic-resistant bacteria. This study analyzed the clinical outcomes and investigated the molecular epidemiology of CRAB bacteremia in a medical center in Northern Taiwan. Methods: We collected 62 blood isolates from patients with CRAB bacteremia from January 2014 to December 2015 at MacKay Memorial Hospital and determined the clonal relationship using the PCR-based technique for molecular epidemiology. Medical charts were reviewed for clinical outcomes. Results: Fifty-six isolates harbored the blaOXA-51-like and blaOXA-23-like carbapenemase genes, 4 isolates harbor the blaOXA-51-like and blaOXA-24-like carbapenemase genes and 2 isolates harbored only the blaOXA-51-like gene. After sequencing, all four isolates of blaOXA-24-like carbapenemase gene were confirmed to be isolates of blaOXA-72 carbapenemase genes. In multivariate analysis in the 60 patients, the independent mortality risk factors of CRAB bacteremia included ≥65 years (elderly) (Odds ratio, 4.04, 95% CI, 1.10–14.83, p = 0.035), chronic kidney disease (4.36, 1.14–16.72, p = 0.032). Isolates harboring the blaOXA-72 gene had the same sequence type (ST218) and PFGE pulsotype raising the possibility of intra-hospital transmission, and all infected patients died. Conclusion: This study showed the clonal relationship of isolates harboring the carbapenemase gene in CRAB bacteremia. Patients with the ST218 strain harboring blaOXA-72 gene had high mortality. This warrants further research to determine the mechanism of virulence and risk factors in order to reduce mortality. Keywords: Acinetobacter baumannii bacteremia, blaOXA-72, Clonal relationship, ST218 |
Databáze: | OpenAIRE |
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