Clinical characteristics of pediatric cutaneous lupus erythematosus: experience from a tertiary referral center in Korea

Autor:	Hee Joo Kim, Joo Young Roh, Soo Kon Lee, J Baek
Rok vydání:	2019
Předmět:	Male medicine.medical_specialty Adolescent Tertiary Care Centers 030207 dermatology & venereal diseases 03 medical and health sciences Lupus Erythematosus Discoid Sex Factors 0302 clinical medicine Rheumatology immune system diseases Republic of Korea Lupus Erythematosus Cutaneous medicine Humans Lupus Erythematosus Systemic Neonatal lupus erythematosus Child skin and connective tissue diseases Retrospective Studies Skin 030203 arthritis & rheumatology business.industry fungi Infant Newborn Infant medicine.disease Dermatology Cross-Sectional Studies Child Preschool Cutaneous Lupus Erythematosus Referral center Female business Pediatric population
Zdroj:	Lupus. 28:888-892
ISSN:	1477-0962 0961-2033
DOI:	10.1177/0961203319851568
Popis:	The clinical characteristics of cutaneous lupus erythematosus (CLE) are well delineated in adults, but pediatric data, particularly in Asian populations, are limited. Therefore, we evaluated the characteristics of pediatric cases by retrospectively reviewing the medical records of children with CLE during a 15-year period in a tertiary care dermatology clinic in South Korea. The study included 21 children (8 males and 13 females), 4 of whom had neonatal lupus erythematosus (NLE). Among 17 patients with CLE, discoid lupus erythematosus (DLE) was most common (47.1%), followed by acute CLE (ACLE, 35.3%). All ACLE cases had systemic lupus erythematosus (SLE). Female predominance was conspicuous in ACLE/SLE (6/11 females versus 0/6 males), as was older age, whereas DLE and NLE showed near-equal sex distributions. The median age at the diagnosis of CLE was significantly higher in females than in males (15 years versus 4.5 years, p = 0.02). All patients with ACLE/SLE simultaneously showed skin and systemic symptoms from onset. The kidney was the most commonly involved organ. This study revealed unique characteristics of pediatric CLE, further warranting a comprehensive review among various ethnicities to understand the wide spectrum of CLE in the pediatric population.
Databáze:	OpenAIRE
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