Body mass index as a classifier to predict biochemical recurrence after radical prostatectomy in patients with lower prostate-specific antigen levels
| Autor: | Mitsuru Nakahara, Shinsuke Fujii, Masanobu Shigeta, Jun Teishima, Yoshimasa Kurimura, Hirotaka Nagamatsu, Akio Matsubara, Yuki Kohada, Keisuke Goto, Yoji Inoue, Koji Mita, Satoshi Maruyama |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Biochemical recurrence Cancer Research medicine.medical_specialty Multivariate analysis Prostatectomy medicine.medical_treatment 030232 urology & nephrology Articles Biology medicine.disease Obesity 03 medical and health sciences Prostate-specific antigen Prostate cancer 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine Body mass index Pathological |
| Popis: | Prostate cancer, one of the most common malignant tumors among men, is closely associated with obesity and, thus far, several studies have suggested the association between obesity and aggressive pathological characteristics in the United States. However, the effect of obesity on prostate cancer mortality is controversial, and it remains unclear whether obesity contributes to the aggressiveness of prostate cancer in Asian patients. The aim of the present study was to investigate the association between body mass index (BMI) and the clinicopathological characteristics of prostate cancer in 2,003 Japanese patients who underwent radical prostatectomy. There was a significant association between higher BMI and higher Gleason score (GS). The multivariate analysis also revealed that BMI was an independent indicator for GS ≥8 at surgery. Moreover, among patients with lower prostate-specific antigen levels, biochemical recurrence-free survival was significantly worse in those with higher BMI. These results suggest that BMI may be a classifier for predicting adverse pathological findings and biochemical recurrence after radical prostatectomy in Japanese patients. |
| Databáze: | OpenAIRE |
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