Metal-based redox-responsive MRI contrast agents
| Autor: | Carlos F. G. C. Geraldes, Éva Tóth, Mário J. F. Calvete, Vanessa A. Tomé, M. Margarida C. A. Castro, Sara M. A. Pinto |
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| Přispěvatelé: | Centro de Química, Department of Chemistry, University of Coimbra, Department of Chemistry, University of Coimbra, Department of Life Sciences, University of Coimbra, Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), LEGOUPIL, Laëtitia |
| Rok vydání: | 2019 |
| Předmět: |
PARACEST agents
Nanoparticle 010402 general chemistry 01 natural sciences Redox Redox Activity Inorganic Chemistry Metal [CHIM] Chemical Sciences MRI contrast agents Materials Chemistry medicine [CHIM]Chemical Sciences Physical and Theoretical Chemistry Redox responsive probes medicine.diagnostic_test 010405 organic chemistry Chemistry Ligand Magnetic resonance imaging Redox responsive Transition metal ions 0104 chemical sciences 3. Good health Metal chelates Relaxation agents Inorganic nanoparticles visual_art visual_art.visual_art_medium Biophysics Hypoxia probes |
| Zdroj: | Coordination Chemistry Reviews Coordination Chemistry Reviews, Elsevier, 2019, 390, pp.1-31. ⟨10.1016/j.ccr.2019.03.014⟩ Coordination Chemistry Reviews, 2019, 390, pp.1-31. ⟨10.1016/j.ccr.2019.03.014⟩ |
| ISSN: | 0010-8545 |
| DOI: | 10.1016/j.ccr.2019.03.014 |
| Popis: | International audience; Given their potential in a better characterization and diagnosis of major pathologies like cancer or chronic inflammation, redox-activated Magnetic Resonance Imaging (MRI) probes have recently attracted much interest from chemists. Such redox responsive probes are capable of reporting on specific biomarkers that are related to tissue redox potential disruption or hypoxia. Lately, this research area has experienced remarkable development, including redox-responsive metal complexes and nanoparticles. Here we critically review the progress with a specific focus on metal-based probes and some nanoparticle examples. We demonstrate, via representative cases, the different molecular mechanisms that can generate a redox-modulated MRI response. They can be based on the redox activity of either the ligand or the metal center, provided the different oxidation states of the metal ion are endowed with different magnetic properties. A particular emphasis is given to recent advances and to the imaging probes that have attained in vivo validation. In overall, we aim to provide the reader with a comprehensive view of how intracellular or extracellular redox buffer systems can be assessed by using MRI contrast agents based on lanthanide or transition metal ions using T1-weighted, T2-weighted, paraCEST 1H or 19F MRI. |
| Databáze: | OpenAIRE |
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