Novel adsorptive type apheresis device Immunopure for ulcerative colitis from clinical perspectives based on clinical trials: Japan and Europe
| Autor: | Yusuke Inoue, Shunichi Yanai, Kazutaka Kukita, Yoshihiro Endo, Kazuya Kitamura, Keisuke Kawasaki, Izumi Hasegawa, Motoki Yonekawa, Ken Kawakami, Masaki Katagiri, Hiroki Nakamura, Kazuhito Kani, Takayuki Matsumoto, Shingo Kato, Tomonari Ogawa, Takuya Doi, Kazuhide Higuchi, Kazuki Kakimoto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty moderate Clinical effectiveness Polyesters therapeutic apheresis 030232 urology & nephrology 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Refractory Internal medicine Humans Medicine In patient Platelet activation Cellulose ulcerative colitis Polyethylene Terephthalates adsorptive device business.industry Remission Induction aggregation polyarylate resin Equipment Design Original Articles Hematology medicine.disease Ulcerative colitis Europe Clinical Practice Clinical trial Apheresis granulocyte Nephrology monocyte Blood Component Removal Colitis Ulcerative Female Original Article Adsorption business leukocyte |
| Zdroj: | Therapeutic Apheresis and Dialysis |
| ISSN: | 1744-9987 1744-9979 |
| DOI: | 10.1111/1744-9987.13661 |
| Popis: | Several adsorptive type devices for ulcerative colitis are used for the induction of remission in patients with active severe disease worldwide. In 2020, the novel apheresis device Immunopure for ulcerative colitis was launched in Japan. Immunopure, like the polyethylene terephthalate column, uses polyarylate, a type of polyester resin, as the adsorbent. Similar to the cellulose acetate column, Immunopure is filled with adsorbent beads and expected to provide ease of use, with minimal risk of column clogging. Immunopure adsorbs leukocytes and platelets, especially activated platelets and platelet‐leukocyte aggregates. In this article, the capability of Immunopure is evaluated from clinical perspective based on a clinical trial in Japan/Europe. As a result, Immunopure is comparable to other products in clinical effectiveness and indicated for the treatment of patients with refractory moderate ulcerative colitis, making it highly useful in clinical practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text