The expression of amphetamine sensitization is dissociable from anxiety and aversive memory: Effect of an acute injection of amphetamine
| Autor: | Demetrio Sierra-Mercado, Rafael Ignacio Gatica, Enzo Pérez-Valenzuela, José Antonio Fuentealba |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Elevated plus maze medicine.medical_treatment Pharmacology Anxiety Motor Activity Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Memory medicine Avoidance Learning Animals Amphetamine Saline Sensitization Working memory General Neuroscience Single injection 030104 developmental biology medicine.anatomical_structure Anesthesia Facilitation Central Nervous System Stimulants medicine.symptom Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuroscience letters. 638 |
| ISSN: | 1872-7972 |
| Popis: | The repeated administration of amphetamine can lead to locomotor sensitization. Although the repeated administration of amphetamine has been associated with anxiety and impaired working memory, it is uncertain if expression of amphetamine sensitization is associated with modifications of emotional memories. To address this issue, rats were injected once daily with amphetamine for five consecutive days (1.5 mg/kg). After four days of withdrawal, rats were delivered an acute amphetamine injection to assess the expression of sensitization. A single exposure to an elevated plus maze (EPM), 24 h after the last injection of amphetamine, showed that amphetamine sensitization is not accompanied by anxiety. Next, aversive memory was assessed using an 11 day inter-trial interval between the EPM Trial 1 and EPM Trial 2. Rats administered with saline showed a percentage of open arms time (% OAT) in Trial 2 that was comparable to Trial 1, demonstrating a reduction in the retrieval of aversive memory. However, rats sensitized after the EPM Trial 1 showed a significant decrease in the % OAT in Trial 2. Importantly, a decrease in the % OAT in Trial 2 compared to Trial 1 was also observed after a single injection of amphetamine 24 h before Trial 2. These results show a facilitation in the retrieval of aversive memory, and suggest that a previous amphetamine injection is enough to produce a protracted activation of neural circuits necessary for the retrieval of aversive memory. |
| Databáze: | OpenAIRE |
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