Asthma: Chronopharmacotherapy and the molecular clock
| Autor: | Masahiro Endo, Satoru Koyanagi, Hiroshi Takane, Yasushi Fukuoka, Hisashi Suyama, Miyako Takata, Shigehiro Ohdo, Takanori Sako, Masanari Watanabe, Masanori Miyata, Hiroki Chikumi, Naoto Burioka, Eiji Shimizu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.drug_class Pharmaceutical Science Ciclesonide Drug Administration Schedule Medication Adherence Pulmonary function testing chemistry.chemical_compound immune system diseases Circadian Clocks Bronchodilator medicine Animals Humans Theophylline Dosing Intensive care medicine Glucocorticoids Asthma business.industry Drug Chronotherapy Respiratory disease respiratory system medicine.disease Bronchodilator Agents respiratory tract diseases chemistry Immunology business medicine.drug |
| Zdroj: | Advanced Drug Delivery Reviews. 62:946-955 |
| ISSN: | 0169-409X |
| DOI: | 10.1016/j.addr.2010.03.012 |
| Popis: | Bronchial asthma is characterized by chronic airways inflammation and reversible airflow limitation. In patients with asthma, symptoms generally worsen during the early hours of the morning, and pulmonary function often deteriorates at the same time, suggesting a role for chronopharmacotherapy. Several drugs for asthma have been developed based on chronopharmacology. Most medications employed for the chronotherapy of asthma are administered once at night with the goal of preventing chronic airway inflammation or development of airflow limitation. In addition to bronchodilators, the inhaled glucocorticosteroid ciclesonide is now available with once-daily dosing, which also improves patients' compliance. Numerous investigations have demonstrated the usefulness of chronotherapy for asthma, especially for patients with nocturnal asthma. This review focuses on chronotherapy of asthma, and also provides a molecular biological explanation for the influence of asthma medications on the clock genes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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