Total plasma clearance of 51Cr-EDTA: Variation with age and sex in normal adults
| Autor: | Dujanah H. Mousa, William Popovich, P Riley, David Hamilton, A al Khader, U J Miola |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Metabolic Clearance Rate Urinary system Inulin Physiology Renal function Kidney chemistry.chemical_compound Pharmacokinetics Reference Values Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Volunteer Edetic Acid Sex Characteristics Inulin Clearance Total plasma business.industry Age Factors General Medicine Middle Aged Chromium Radioisotopes Tissue Donors Endocrinology chemistry Injections Intravenous Regression Analysis Female business Sex characteristics |
| Zdroj: | Nuclear Medicine Communications. 21:187-192 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-200002000-00011 |
| Popis: | Although inulin clearance measured during constant infusion is still considered the reference method, single-injection of 51Cr-EDTA with subsequent plasma sampling has become the most popular technique for the routine assessment of glomerular filtration rate. Despite the fact that the technique has been in use for 30 years, there are only a few reports of normal values calculated directly from 51Cr-EDTA data and normal ranges have generally been produced by conversions of inulin data. The aim of this study was to measure the variation in total plasma clearance, calculated directly from 51Cr-EDTA measurements, in normal males and females, of Saudi Arabian origin, over a wide range. Altogether, 201 potential kidney donors aged 16-60 years were studied. No statistically significant association of total plasma clearance with age or sex could be demonstrated; however, predictive equations suggesting a small decline in total plasma clearance with age were developed. The figures presented suggest that the reduction in total plasma clearance of 51Cr-EDTA with age is relatively shallow up to the age of at least 60 years and that normal ranges produced by conversion of inulin data may overestimate the decline with age. |
| Databáze: | OpenAIRE |
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