Long noncoding RNAs in hematopoietic malignancies
| Autor: | Norma I. Rodriguez-Malave, Dinesh S. Rao |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Regulation of gene expression Genetics Cell General Medicine Computational biology Biology Lncrna expression Biochemistry Chromatin remodeling Long non-coding RNA Gene Expression Regulation Neoplastic 03 medical and health sciences Haematopoiesis 030104 developmental biology medicine.anatomical_structure Hematologic Neoplasms RNA splicing Transcriptional regulation medicine Humans RNA Long Noncoding Molecular Biology |
| Zdroj: | Briefings in Functional Genomics. 15:227-238 |
| ISSN: | 2041-2657 2041-2649 |
| DOI: | 10.1093/bfgp/elv047 |
| Popis: | Recent years have witnessed the discovery of several classes of noncoding RNAs (ncRNAs), which are indispensable for the regulation of cellular processes. Many of these RNAs are regulatory in nature with functions in gene expression regulation such as piwi-interacting RNAs, small interfering RNAs and micro RNAs. Long noncoding RNAs (lncRNAs) comprise the most recently characterized class. LncRNAs are involved in transcriptional regulation, chromatin remodeling, imprinting, splicing, and translation, among other critical functions in the cell. Recent studies have elucidated the importance of lncRNAs in hematopoietic development. Dysregulation of lncRNA expression is a feature of various diseases and cancers, and is also seen in hematopoietic malignancies. This article focuses on lncRNAs that have been implicated in the pathogenesis of hematopoietic malignancies. |
| Databáze: | OpenAIRE |
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