Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome
| Autor: | Laura L. Read, Catherine L. Clelland, Laura J. Panek, Amanda N. Baraldi, Corinne P. Bart, James D. Clelland, Carrie A. Pappas, Robert H. Nadrich |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Proline behavioral disciplines and activities Article Proline Measurement Young Adult Proline dehydrogenase Internal medicine mental disorders Brief Psychiatric Rating Scale Proline Oxidase Humans Medicine Enzyme Inhibitors Psychiatry Amino Acid Metabolism Inborn Errors Biological Psychiatry Aged Analysis of Variance Chi-Square Distribution Proline oxidase business.industry Valproic Acid Case-control study Middle Aged medicine.disease 1-Pyrroline-5-Carboxylate Dehydrogenase Psychiatry and Mental health Cross-Sectional Studies Schizophrenia Case-Control Studies Hyperprolinemia Female business |
| Zdroj: | Schizophrenia Research. 131:139-145 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2011.05.006 |
| Popis: | There are multiple genetic links between schizophrenia and a deficit of proline dehydrogenase (PRODH) enzyme activity. However, reports testing for an association of schizophrenia with the resulting proline elevation have been conflicting. The objectives of this study were to investigate whether hyperprolinemia is associated with schizophrenia, and to measure the relationship between plasma proline, and clinical features and symptoms of schizophrenia. We performed a cross-sectional case-control study, comparing fasting plasma proline in 90 control subjects and 64 schizophrenic patients and testing for association of mild to moderate hyperprolinemia with schizophrenia. As secondary analyses, the relationship between hyperprolinemia and five measures of clinical onset, symptoms and outcome were investigated. Patients had significantly higher plasma proline than matched controls (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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