CNP causes receptor-mediated positive dromotropic effects in anesthetized dog hearts
| Autor: | Yusuke Miyashita, Masato Tsuboi, Koichi Nakajima, Fumio Kurogouchi, Yasuyuki Furukawa, Shigetoshi Chiba, Masamichi Hirose |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.drug_class Hemodynamics Propranolol Isosorbide Dinitrate Injections Dogs Atrial natriuretic peptide Polysaccharides Physiology (medical) Internal medicine medicine Natriuretic peptide Animals business.industry Electric Conductivity Proteins Heart Natriuretic Peptide C-Type Coronary Vessels Atrioventricular node Electric Stimulation Perfusion medicine.anatomical_structure Endocrinology Guanylate Cyclase Circulatory system Dromotropic Atrioventricular Node Cardiology Female Cardiology and Cardiovascular Medicine business Receptors Atrial Natriuretic Factor Blood Flow Velocity medicine.drug Blood vessel |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 275:H717-H720 |
| ISSN: | 1522-1539 0363-6135 |
| DOI: | 10.1152/ajpheart.1998.275.2.h717 |
| Popis: | No data are available for the direct effect of C-type natriuretic peptide (CNP) on atrioventricular (AV) conduction in mammalian hearts. Thus we studied the dromotropic effects of CNP-22 injected into the AV node artery in autonomically decentralized hearts in open-chest, anesthetized dogs. CNP decreased AV interval (AV conduction time) in a dose-dependent manner with increase in coronary artery blood flow rate in six anesthetized dogs. Isosorbide dinitrate did not affect AV interval, but it increased coronary artery blood flow rate. A guanylyl cyclase-linked natriuretic peptide receptor antagonist, HS-142–1, inhibited the decreases in AV interval and the increases in coronary blood flow rate in response to CNP, whereas propranolol did not affect the positive dromotropic response to CNP. These results demonstrate that CNP decreases AV interval and increases coronary artery blood flow rate mediated by a guanylyl cyclase-linked natriuretic peptide receptor, but not β-adrenoceptor, in the dog heart. |
| Databáze: | OpenAIRE |
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