Genetic variants in RTEL1 influencing telomere length are associated with prostate cancer risk
| Autor: | Yao Zhu, Sheng Ming Jin, Dai Bo, Cheng Yuan Gu, Guo Wen Lin, Xiao Jian Qin, Guo Hai Shi, Dingwei Ye |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology telomere medicine.medical_specialty Single-nucleotide polymorphism Disease Odds ratio Biology prostate cancer medicine.disease susceptibility Confidence interval Telomere 03 medical and health sciences Prostate cancer 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine SNP polymorphisms Gene Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between genetic variants in three telomere length-related genes and PCa risk in a case-control study. The influence of these variants on the leukocyte telomere lengths was then appraised by real-time PCR. RTEL1 rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, P = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk. These two risk single nucleotide polymorphisms (SNPs) (OR: 0.59; 95% CI: 0.39-0.89, P = 0.012 and OR: 0.58; 95% CI: 0.38-0.87, P = 0.009, respectively) and another SNP PARP1 rs1136410 (OR: 1.53; 95% CI: 1.01-2.31, P = 0.043) were also associated with leukocyte telomere length. These findings support that genetic determinants of telomere length may influence PCa risk. |
| Databáze: | OpenAIRE |
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