Alloantibodies and outcomes of deceased donor kidney allografts
| Autor: | Quirino Lai, Massimo Rossi, M.L. Tamburro, Paola Cinti, P.B. Berloco, Luca Poli, Renzo Pretagostini |
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| Rok vydání: | 2009 |
| Předmět: |
Cytotoxicity
Immunologic Graft Rejection Isoantigens T-Lymphocytes Immunology Population Actuarial survival Immune system Isoantibodies alloantibodies kidney transplantation Cadaver medicine Humans Transplantation Homologous Immunology and Allergy education Immunosorbent Techniques Kidney transplantation Monitoring Physiologic Immunosuppression Therapy Deceased donor kidney B-Lymphocytes Immunity Cellular education.field_of_study biology business.industry Incidence Complement System Proteins General Medicine Flow Cytometry medicine.disease Kidney Transplantation Tissue Donors Transplantation Antibody Formation biology.protein Immunization Antibody business Follow-Up Studies |
| Zdroj: | Human Immunology. 70:651-654 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2009.06.008 |
| Popis: | Analysis of the anti-HLA antibody status of 100 recipients of kidneys from deceased donors demonstrated that presensitization and the development of alloantibodies after transplantation are associated with the development of antibody mediated as well as cellular rejection. This finding indicates that the humoral arm of the immune response is also involved in cell-mediated rejection and/or that there may be a continuum between these two forms of rejection. Most episodes of rejection were successfully reversed in our population, as shown by the overall 3-year actuarial survival of 98% in nonsensitized and 91% in sensitized recipients, emphasizing the importance of comprehensive antibody studies. |
| Databáze: | OpenAIRE |
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