The profiling of plasma free amino acids and the relationship between serum albumin and plasma-branched chain amino acids in chronic liver disease: a single-center retrospective study
| Autor: | Jun Inoue, Takuya Nakamura, Tooru Shimosegawa, Eiji Kakazu, Akitoshi Sano, Teruyuki Umetsu, Takayuki Kogure, Masashi Ninomiya, Tatsuki Morosawa, Satoshi Takai, Tomoaki Iwata |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Cirrhosis Serum albumin Single Center Chronic liver disease Severity of Illness Index digestive system Gastroenterology 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Hypoalbuminemia Serum Albumin Aged Retrospective Studies chemistry.chemical_classification biology Liver Cirrhosis Biliary business.industry Liver Diseases Retrospective cohort study Hepatitis C Chronic Middle Aged Hepatology medicine.disease digestive system diseases Amino acid 030104 developmental biology chemistry Chronic Disease Disease Progression biology.protein Tyrosine Female 030211 gastroenterology & hepatology business Amino Acids Branched-Chain |
| Zdroj: | Journal of Gastroenterology. 53:978-988 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/s00535-018-1435-5 |
| Popis: | It is poorly understood how an imbalance of plasma-free amino acids (PFAAs) occurs and how the imbalance shows an association with the serum albumin (sAlb) level during the progression of chronic liver disease (CLDs). The aim of this study is to elucidate the profiles of PFAAs and the relationship between sAlb and PFAAs in recent patients with CLDs during the progression. We retrospectively evaluated the 1569 data of PFAAs data obtained from 908 patients with various CLDs (CHC, CHB. alcoholic, NAFLD/NASH, PBC, AIH, PSC, and cryptogenic). In total, 1140 data of PFAAs could be analyzed in patients with CLDs dependent of their Child–Pugh (CP) score. Various imbalances in PFAAs were observed in each CLDs during the progression. Univariate and multivariate analysis revealed that among 24 PFAAs, the level of plasma-branched chain amino acids (pBCAAs) was significantly associated with the CP score, especially the sAlb score, in patients with chronic hepatitis C virus (CHC), NAFLD/NASH and PBC. The correlation coefficient values between sAlb and pBCAAs-to-Tyrosine ratio (BTR) in these patients were 0.53, 0.53 and 0.79, respectively. Interestingly, although the pBCAAs in NAFLD/NASH patients varied even when the sAlb was within the normal range, the pBCAAs tended to be low when the sAlb was below the normal range. Although a decrease in the level of pBCAAs was observed during the progression regardless of the CLD etiology, the level of total pBCAAs was independently associated with the sAlb level in the PFAAs of CHC, PBC and NAFLD/NASH. The correlation between sAlb and BTR showed the highest value in PBC patients among the patients with CLDs. A decrease in pBCAAs often occurred in NASH even when the sAlb level was kept in the normal range. |
| Databáze: | OpenAIRE |
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