Molecular detection of Orientia tsutsugamushi strains circulating in Nagaland

Autor:	Siraj A. Khan, Jahnabi Saikia, Trishna Bora, Vinotsole Khamo, Manju Rahi
Rok vydání:	2022
Předmět:	Microbiology (medical) General Immunology and Microbiology Immunology India Sequence Analysis DNA Microbiology Polymerase Chain Reaction Orientia tsutsugamushi Infectious Diseases Immunology and Microbiology (miscellaneous) Scrub Typhus Immunology and Allergy Humans Phylogeny
Zdroj:	Indian journal of medical microbiology. 40(3)
ISSN:	1998-3646
Popis:	The antigenic heterogeneity of Orientia in India is still unknown in many disease endemic areas. The present study aims to characterize the strains of O. tsutsugamushi circulating in Nagaland, Northeast India. Two patients clinically diagnosed with ST and hospitalized in Mon district hospital, Nagaland were identified from whom eschar tissues were collected. Both patients demonstrated antibodies against O. tsutsugamushi along with positive PCR amplification for 56 ​kDa gene. The prototype strain TA763 shared 90.4% homology with the sequences. Both the sequences formed a distinctive cluster demonstrating 100% similarity with strains identified from Thailand, Vietnam, China and southern parts of India.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e560f886c9bc63926b59a709493364e7 https://pubmed.ncbi.nlm.nih.gov/35527118 Zobrazit plný text záznamu Full Text from ScienceDirect