Bone Modeling Indexes at Onset and During the First Year of Follow-Up in Insulin-Dependent Diabetic Children
| Autor: | C. Prinster, Riccardo Bonfanti, Franco Meschi, Stefano Mora, Giuseppe Chiumello, E. Bognetti, M. Puzzovio, Maria Carla Proverbio |
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| Přispěvatelé: | Bonfanti, R, Mora, S, Prinster, C, Bognetti, E, Meschi, F, Puzzovio, M, Proverbio, Mc, Chiumello, G |
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Bone resorption Cohort Studies Endocrinology N-terminal telopeptide Reference Values Internal medicine Diabetes mellitus medicine Humans Insulin Orthopedics and Sports Medicine Child Glycated Hemoglobin Bone Development C-Peptide business.industry Body Weight medicine.disease Body Height Peptide Fragments Osteopenia Bone Diseases Metabolic Diabetes Mellitus Type 1 Basal (medicine) Metabolic control analysis Regression Analysis Female Collagen Complication business Biomarkers Procollagen Follow-Up Studies |
| Zdroj: | Calcified Tissue International. 60:397-400 |
| ISSN: | 1432-0827 0171-967X |
| DOI: | 10.1007/s002239900251 |
| Popis: | Osteopenia has been described as a complication of insulin-dependent diabetes mellitus (IDDM). We measured bone modeling indexes during the first year of IDDM. At each time point the values obtained from diabetic children have been compared with those of control subjects. We selected 27 prepubertal children with IDDM (6.35 +/- 2.16 years). We also enrolled 30 healthy prepubertal children of comparable age (5.85 +/- 3.05 years). Height, height standard deviation scores, glycated haemoglobin (HbA(1C)), basal c-peptide concentrations, insulin dose, serum concentrations of procollagen type I C-terminal propeptide (PICP), and collagen type I C-terminal telopeptide (ICTP) were measured at onset of IDDM and at 3, 6 and 12 months. ICTP was in the normal range at onset of IDDM and decreased during the follow-up to reach a significant difference compared to controls after 3, 6 and 12 months of insulin treatment (P < 0.04). PICP concentrations increased significantly at 3 months (P = 0.05) compared to onset. At 3 and 12 months PICP values were significantly higher than those of control children (P = 0.04). Correlations were found be tween PICP concentrations and HbA(1C) and c-peptide at onset of diabetes (r = -0.45 and r = 0.47, respectively). Bone formation at onset of IDDM is not impaired; the introduction of insulin therapy, together with the achievement of a good metabolic control, determines an increase of bone matrix formation coupled with a decrease of bone resorption, that determines a positive balance of bone modeling. |
| Databáze: | OpenAIRE |
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