Immunofluorescent Microscopy Findings In Minimal or No Change-Disease and Slight Generalised Mesangioproliferative Glomerulonephritis
| Autor: | Svend Larsen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Systemic disease Pathology medicine.medical_specialty Adolescent Kidney Glomerulus Fluorescent Antibody Technique Disease Nephropathy Glomerulonephritis Humans Medicine Child Aged Kidney biology business.industry Immune Sera Nephrosis Lipoid Complement C3 General Medicine Middle Aged medicine.disease Immunoglobulin A Microscopy Electron Upper respiratory tract infection medicine.anatomical_structure Immunoglobulin M Immunoglobulin G biology.protein Female Antibody business Kidney disease |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Section A Pathology. :531-542 |
| ISSN: | 0365-4184 |
| DOI: | 10.1111/j.1699-0463.1978.tb02080.x |
| Popis: | Seventy-two kidney biopsies from patients with clinical evidence of glomerulonephritis (GN) were examined by immunofluorescent microscopy (IFM) using 1 μm cryostat sections and optimal excitation interference filters. The biopsies were classified at light microscopy (LM) as normal, minimal lesion, or mild generalised proliferative GN. As a spot check on the LM diagnosis 19 biopsies were examined by electron microscopy (EM). Comparison of IFM findings and the clinical symptoms and clinical course of the disease showed: 1 that in patients with deposits of IgG-IgA/C3, haematuria and systemic disease were significantly more frequent, and there was less tendency to complete remission, than in patients with other deposits. 2 that IgG-IgA nephropathy is probably brought by C3 activation through the alternative pathway. 3 that all biopsies with deposits of IgA/C3 were from patients with a clinical history of previous, recurring upper respiratory tract infection. 4 that 18 out of 19 biopsies, where no deposits could be demonstrated, were from patients with no clinical history or clinical evidence of infection. Apart from this no significant correlation was found between the fluorescent findings and clinical symptoms in GN or its clinical course. No specific IFM findings could be related to any of the LM changes. IFM results therefore suggest that the presence of some immunoglobulins may be interpreted as showing involvement of immune mechanisms only at a purely secondary level. However, this does not exclude the possibility that immunoglobulin deposits can be of importance for the development of a protracted or perhaps chronic course in the disease, and therefore the importance of deposits should first be assessed after a longer period of years than in the present work. |
| Databáze: | OpenAIRE |
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