In vitro and in vivo behavior of ketoprofen intercalated into layered double hydroxides
| Autor: | Mihaela Silion, I.M. Jaba, Ionel Marcel Popa, Doina Hritcu, D.G. Ionescu, Bogdan Ionel Tamba, O. C. Mungiu |
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| Rok vydání: | 2010 |
| Předmět: |
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Ketoprofen Polymers Stereochemistry Chemistry Pharmaceutical Kinetics Intercalation (chemistry) Biomedical Engineering Biophysics Bioengineering engineering.material Dosage form Biomaterials Mice X-Ray Diffraction Spectroscopy Fourier Transform Infrared Hydroxides medicine Animals Stomach Ulcer Fourier transform infrared spectroscopy Pain Measurement Drug Carriers Fenbufen Hydrotalcite Chemistry Anti-Inflammatory Agents Non-Steroidal Layered double hydroxides Gastrointestinal Tract Treatment Outcome engineering medicine.drug Nuclear chemistry |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 21:3009-3018 |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-010-4151-0 |
| Popis: | Ketoprofen (Ket) was intercalated into layered double hydroxides (ZnAlLDH and MgAlLDH) using the ionic exchange method. The drug intercalation was confirmed by X-ray diffraction (XRD) and FTIR spectroscopy. Ket release from the inorganic matrix was studied at pH 7.4 in continuous regime with a flow rate of 0.5 and respectively 1.0 ml/min. The kinetical data were interpreted using the Ritger and Peppas model. The data prove that the release kinetics and mechanism depend on the eluent flow rate. Quantification of gastric tolerance shows that the ulcerogenic effect of the intercalated drug is lower than the one of the raw Ket. The antinociceptive effect of both formulations was studied by the hot-plate method performed on mice. The MgAlLDH_Ket formulation shows a tendency towards a stronger antinociceptive effect than its ZnAlLDH_Ket counterpart during the 210 min recorded period. |
| Databáze: | OpenAIRE |
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